BME 5306 - Gene Engin/Synth Bio

Institution:

University of Utah

Subject:

Biomedical Engineering

Description:

Cells have a remarkable ability to continuously sense, integrate, and store relevant physiological and biological information throughout their lives. They integrate many signals that surround them, and execute complex cellular behaviors based on these inputs. These attributes can be harnessed and manipulated using synthetic biology to tightly control gene expression in dynamic patterns, in addition to programming cells to sense, respond, and record changes in their microenvironment. Altogether, approaches in synthetic biology can be used to reprogram cells in rational and systematic ways to produce predictable and robust cellular behavior for many biotechnology applications. This new course will introduce advanced undergraduate and graduate students to the principles of genetic engineering, synthetic biology and the design of biological machines. We will discuss parts, devices and systems in DNA assembly for genetic engineering and synthetic biology applications. Students will learn about network structure, pathway engineering, and ultimately understand how synthetic networks can be simulated, built, and tested in a real organism. Specific topics will include various ways to control gene expression in biological systems, and examples will be discussed to demonstrate how intracellular components interact to give the observed biological behavior. Specifically, we will discuss engineering cellular Boolean logic gates, biosensors, endowing cells with memory, switches, oscillators, noise in cellular systems, feedback, and computational modeling of cellular networks.

Credits:

3.00

Credit Hours:

Prerequisites:

Corequisites:

Exclusions:

Level:

Instructional Type:

Lecture

Notes:

Additional Information:

Historical Version(s):

Institution Website:

www.utah.edu

Phone Number:

(801) 581-7200

Regional Accreditation:

Northwest Commission on Colleges and Universities

Calendar System:

Semester

General Education

• No items found

The Course Profile information is provided and updated by third parties including the respective institutions. While the institutions are able to update their information at any time, the information is not independently validated, and no party associated with this website can accept responsibility for its accuracy.